Protein-tyrosine phosphatases in development

Protein-tyrosine phosphatases in development

One of the most important mechanisms of eukaryotic signalling is protein phosphorylation on tyrosine residues, which plays a pivotal role in development by regulating cell proliferation, differentiation and migration. Cellular phosphotyrosine (P.Tyr) levels are regulated by the antagonistic activities of the protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). We have good ...

Protein tyrosine phosphatases.

The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases has lagged behind, but is now gathering momentum and is predicted to become a "hot top...

Asthma Development in a Murine Asthma Protein Tyrosine Phosphatases Regulate

Receptor protein tyrosine phosphatases in nervous system development.

Receptor protein tyrosine phosphatases (RPTPs) are key regulators of neuronal morphogenesis in a variety of different vertebrate and invertebrate systems, yet the mechanisms by which these proteins regulate central nervous system development are poorly understood. In the past few years, studies have begun to outline possible models for RPTP function by demonstrating in vivo roles for RPTPs in a...

Hepatic protein tyrosine phosphatases in the rat.

Regulation of cell growth and metabolism by protein tyrosine phosphorylation involves dephosphorylation via the action of protein tyrosine phosphatases (PTPases). We have characterized the membrane PTPases in rat liver, monitoring their activity by measuring the dephosphorylation of P-Tyr-reduced, carboxyamidomethylated and maleylated lysozyme (P-Tyr-RCML) and P-Tyr-myelin basic protein (P-Tyr-...